异步控制Varicol工艺分离愈创木酚甘油醚对映体过程研究

摘要

Chiral separation by simulated moving bed technology has become an important process. In this work, an advanced simulated moving bed technology (Varicol process) was investigated to separate guaifenesin enantiomers on Chrialcel OD stationary phase using a mixture of ethanol and n-hexane as mobile phase. Based on asynchronous shift of inlet and outlet lines, a mathematical model was established and solved using the finite element model of orthogonal collocation. The evolution of axial internal concentration profile inside the columns was presented to analyze the influence of discrete switch on separation of guaifenesin enantiomers. The separation region of guaifenesin enantiomers by the 5-column (1-1.5-1.5-1) Varicol process was designed, the operating condition of single enantiomer with 99% purities was determined and its feasibility was validated by Varicol experiment. Both experimental and simulated results would facilitate operation and design of the Varicol process.%模拟移动床技术已经成为手性化合物拆分的重要手段。以Chiralcel OD为固定相、乙醇/正己烷混合物为流动相，采用一种先进的模拟移动床技术（Varicol工艺）分离愈创木酚甘油醚对映体。针对进出料口位置异步切换模式建立了Varicol工艺数学模型，采用有限元正交配置法对模型进行求解。从初始循环内愈创木酚甘油醚对映体内部浓度的时间进程曲线分析了Varicol工艺的分离过程。并且设计了5柱(1-1.5-1.5-1)构态的Varicol工艺分离愈创木酚甘油醚操作区，确定了获得单一对映体产品纯度99%的分离条件，通过实验数据进行了验证。理论和实验研究可以为Varicol工艺的工业应用提供基础依据。