纳洛酮治疗急性重症脑损伤疗效初步观察

摘要

目的　探讨纳洛酮对急性重症脑外伤的治疗效果。方法　采取分组对照，一组用常规综合治疗，一组用纳洛酮加综合治疗。而后进行用药前、用药后以及3～6个月后进行量化评定，GCS、GOS、语言功能和运动功能恢复等级。结果　应用纳洛酮治疗组死亡4例(20%)、生存者恢复良好8例(40%)、中残6例(30%)、重残2例(10%)。与对照组比较卡方检验P<0.01有显著差异。结论　纳洛酮治疗有助于降低急性重症脑外伤的病死率、伤残率，提高生存质量。%Objective　To explore treatment effect of naloxone on the severe brain injuries.Methods　All cases were divided into two groups with 20 cases each: routine treatment group and Naloxone treatment group. GCS、GOS recovery rank score of speech and mobility were evaluated before and after treament.Results　 In Naloxone treatment group 4 cases dead,8 cases good recovery, 6 cases moderate deficit,2 cases severe deficit. The treatment effect of Naloxone group was significantly different from that of routine treatment group (P<0.01).Conclusion　Naloxone treatment can diminsh mortality and cut down the disability rate for severe brain injuries.