腹股沟直疝患者腹横筋膜MMP-2及TIMP-2的表达研究

摘要

Objective To investigate the expressions of MMP-2 and TIMP-2 in the transversalis fascia of direct inguinal hernia and explore the pathogenesis of the disease.Methods Herniorrhaphy was performed in 30 patients with inguinal hernia(13 direct and 17 indirect),and the expressions of MMP-2 and TIMP-2 in the transversalis fascia were examined by using immunohistochemistry.Results An increased expression of MMP-2 and a reduced expression of TIMP-2 in the transversalis fascia were found in direct inguinal hernia when compared with indirect inguinal hernia.Conclusion The disordered expressions of MMP-2 and TIMP2 in transversalis fascia might be associated with the development of direct inguinal hernia.%目的 比较基质金属蛋白酶-2(MMP-2)及基质金属蛋白酶组织抑制因子-2(TIMP-2)在腹股沟直疝患者腹横筋膜的表达,探讨腹股沟直疝的发病机制.方法 用免疫组化方法检测2008年12月至2009年10月在承德医学院附属医院行疝修补术的13例直疝与17例斜疝患者腹横筋膜中MMP-2及TIMP-2蛋白的表达情况.结果 直疝患者腹横筋膜MMP-2蛋白含量显著高于斜疝患者(P＜0.05),TIMP-2蛋白含量显著低于斜疝患者(P＜0.05).结论 腹股沟直疝患者腹横筋膜MMP-2及TIMP-2蛋白的异常变化是其发病原因之一.