Objective To detect the expression of Cox-2 and MMP-2 in invasive breast carcinoma,and explore their correlation.Methods The expression of Cox-2 and MMP-2 were studied in 100 cases of invasive breast carcinoma by SP immunohistochemistry.Results The positive expression of Cox-2 protein in normal breast tissue and breast carcinoma were7.5％ (3/40) and 83.0％(83/100) respectively,and the positive rate of Cox-2 in the lymph node metastasis(54/60) was significantly higher than those without lymph node metastasis(P＜0.05).The positive expression of MMP-2 protein in normal breast tissue and breast carcinoma were 0(0/40)and 94.0％ (94/100) respectively, and the positive rate of MMP-2 in the lymph node metastasis( 59/60) was significantly higher than those without lymph node metastasis(P＜0.05).Positive correlation could be found between the expression of Cox-2and that of MMP-2 as well(r=0.334,P＜0.01).Conclusion Cox-2 and MMP-2 protein are highly expressed in breast carcinoma,and are all related with lymph node metastasis.These proteins are indicators of metastasis and predictors for prognosis of breast carcinoma.%目的 探讨环氧合酶-2(COX-2)、基质金属蛋白酶-2(MMP-2)在乳腺浸润性癌中的表达情况及它们之间的相互关系.方法 采用免疫组化SP法检测100例乳腺癌及40例正常乳腺组织中COX-2、MMP-2的表达情况.结果 COX-2蛋白在正常乳腺组织及乳腺癌中的阳性表达率分别为7.5%(3/40)、83.0%(83/100),而且COX-2在淋巴结转移组中的阳性表达率[90.0%(54/60)]明显高于无淋巴结转移组(P＜0.05).MMP-2蛋白在正常乳腺组织及乳腺癌中的阳性表达率分别为0(0/40)、94.0%(94/100),而且MMP-2在淋巴结转移组中的阳性表达率[98.3%(59/60)]明显高于无淋巴结转移组[87.5%(35/40)](P＜0.05).COX-2和MMP-2表达呈正相关关系(r=0.334,P<0.05).结论检测COX-2、MMP-2表达将有助于判断乳腺癌的转移潜能及预后.
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