341例原发性食管鳞癌术后生存期及影响因素分析

摘要

Objective To explore the factors related to the prognosis and survival duration of esophageal squamous cell carcino ma after operation.Methods 341 esophageal squamous cell carcinoma cases undergoing operation in our hospital from 2000 to 2008 were selected and related clinical data were analyzed.Kaplan-Meier analysis and Cox regression analysis was used for univariate a nalysis and multivariable analysis,respectively.Results The survival rate for one year was about 63％ ,51％ for two years and 36％for five years.Univariate analysis showed that TNM classification, tumor location, differentiation, invasion depth, lymph node metastasis significantly correlated with survival rates (P＜0.05).Multivariable analysis showed that lymph node metastasis was an independent prognostic factor of esophageal squamous cell carcinoma (P＜0.05).Conclusion Many factors are related to the prognosis and survival duration of esophageal squamous cell carcinoma after operation.Lymph node metastasis is an independent prognostic factor affecting esophageal squamous cell carcinoma.%目的 探讨影响原发性食管鳞癌生存时间的因素,为预测预后提供依据.方法 对2000 年01月至2008 年12 月在江苏大学附属宜兴市人民医院进行食管癌根治性切除手术患者定期随访.采用Kaplan-Meier生存率分析和Cox 比例风险模型进行单因素和多因素分析.结果 患者术后1、2年与5年生存率分别为63%、51%和36%.单因素分析显示TNM 分期、肿瘤浸润深度、淋巴结转移、肿瘤部位及肿瘤分化程度与术后患者的生存率相关(P＜0.05); Cox 分析显示,淋巴结转移是影响食管癌预后的独立因素(P＜0.05).结论 多种因素影响食管鳞癌患者预后,淋巴结转移可作为食管鳞癌患者预后判断的独立因素.