目的 分析原发性甲状腺恶性淋巴瘤(PTL)的临床表现、诊断、治疗及预后.方法 回顾性分析该院1990年1月至2010年12月收治的13例PTL患者的临床资料.结果 5例患者术前行细针穿刺细胞学(FNAC)检查,其中仅2例诊断为PTL.所有患者均行手术切除,术后有12例患者进一步行全身化疗,化疗患者中还有8名接受放疗.中位随访时间为30个月(10～125个月),3年总生存率和3年无进展生存率分别为66.1%和58.7%.结论 临床上发现迅速增大的甲状腺肿物时需要考虑PTL的可能.FNAC检查对于确诊PTL作用有限,但可以起到一定的提示作用.手术的作用主要是明确诊断及缓解症状,放疗及化疗是PTL的主要治疗手段.%Objective To analyze the clinical manifestation, diagnosis, treatment and prognosis of primary thyroid lymphoma (PTL). Methods The general information,clinical and pathologic classification,treatment method of 13 cases with PTL diagnosed and managed in our department between January 1990 to December 2010 were reviewed retrospectively. Results 5 patients under went fine needle aspiration cytology(FNAC) ,and the results were highly suggestive of PTL in only 2 patients. Surgical resection was performed in all patients. 12 patients received combination chemotherapy after surgery and 8 of them received additional irradia tion. With a median follow up of 30(10 ?25) months,3 years over all survival rate was 66. 1 % ,and 3 years progression free sur vival rate was 58. 7%. Conclusion The diagnosis of PTL should be considered when dealing with rapidly growing thyroid. The role of FNAC in diagnosing thyroid lymphoma is limited but it is still useful in the initial work up. Nevertheless,surgical intervention is often required to establish the diagnosis and relieve the symptoms. A combination of chemotherapy and irradiation is the mainstay of management.
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