PS联合NIPPV救治新生儿呼吸窘迫综合征的疗效观察

摘要

目的 探讨肺表面活性物质(PS)联合经鼻间歇正压通气(NIPPV)救治新生儿呼吸窘迫综合征(NRDS)的疗效.方法 对38例NRDS患儿进行PS联合NIPPV治疗,在治疗过程中进行精心的整体护理,并观察其疗效.结果 NIPPV与PS联合治疗能明显改善NRDS患儿心率、呼吸频率及血气分析各项指标,与治疗前比较,患儿心率、呼吸频率及PaCO2明显降低,PaO2明显升高,差异有统计学意义(P<0.05).结论 NRDS采用PS联合NIPPV治疗能有效减少气管擦管机械通气的使用比例,对于部分可能需要气管插管的NRDS患儿,避免了因气管插管可能带来的严重并发症.%Objective To explore the therapeutic effects of the combination of pulmonary surfactant (PS) and nasal intermittent positive pressure ventilation (NIPPV) in treating neonatal respiratory distress syndrome (NRDS). Methods 38 cases of NRDS were treated with the combination of PS and NIPPV. The elaborate holistic nursing was performed during the treatment process and the curative effects were observed. Results The combination of PS and NIPPV could significantly improve the various parameters of heart rate, blood gas and breathing frequency. After the treatment, HR, respiratory frequency and PaC()2 were decreased, but PaO2 was increased, with statistical difference(P<0. 05). Conclusion The combination of PS and NIPPV for treating NRDS can effectively decrease the use proportion of tracheal intubation and mechanical ventilation. In partial NRDS neonates needing tracheal intubation possibly, the serious complications caused by tracheal intubation could be avoided.