血管紧张素原基因M235T多态性与原发性高血压相关性的Meta分析

摘要

Objective To evaluate the association of angiotensin (AGT ) gene M235T polymorphism with essential hypertension (EH) .Methods The literatures examining the association of the M 235T polymorphisms with EH were selected in electronic data-bases .Using RevMan5 .0 ,heterogeneity and pooled effect sizes were calculated .Results Totally ,29 articles ,with 5 971 cases and 6 443 controls were finally included in this study .The odds ratio (OR) value of TT+ TM∶MM genotype was 1 .13 (95% CI 1 .00-1 .25 ,P=0 .04) in worldwide populations .Subgroup analysis showed that the OR values of TT ∶MM genotype were 1 .13 (95% CI 0 .90-1 .42 ,P=0 .28) in subjects published before 2008 and 1 .29(95% CI 0 .94-1 .75 ,P=0 .11) in those after 2008(year of 2008 included) .The OR values of T ∶M in Han population was 1 .24 (95% CI 1 .01-1 .53 ,P=0 .04) .Conclusion TT+ TM genotype of the M235T polymorphisms is associated with EH in worldwide populations ,and T allele is also correlated with EH in Han popu-lation .%目的：评价血管紧张素原（AGT）基因M235T多态性与原发性高血压（EH）的相关性。方法检索数据库中符合纳入AGT基因M235T多态性与EH关系的文献，应用RevMan5．0软件对结果进行异质性分析和效应值合并。结果共纳入29篇文献，其中EH组5971例，对照组6443例。总研究人群基因型 TT＋ TM ∶MM 的 OR为1．13（95％ CI 1．00～1．25，P＝0．04）。按文献发表年限进行亚组分析，基因型TT∶MM在2008年之前及2008年之后（含2008年）两组 OR分别1．13（95％ CI 0．90～1．42，P＝0．28）、1．29（95％ CI 0．94～1．75，P＝0．11）。汉族人群 T∶M 的 OR为1．24（95％ CI 1．01～1．53，P＝0．04）。结论全球总体人群AGT基因M235T多态性基因型TT＋ TM与EH有关，同时汉族人T等位基因与EH有关。