目的 探讨外周血中胸苷酸合成酶(TS)和二氢嘧啶脱氢酶(DPD)mRNA对晚期胃癌患者接受替吉奥(S-1)治疗疗效的预测价值.方法 24 例晚期胃癌患者均接受口服S-1化疗,采用逆转录聚合酶链反应技术(RT-PCR)检测患者外周血中DPD mRNA和TS mRNA的表达,观察其表达与化疗疗效的关系.结果 TS mRNA低表达组的S-1化疗有效率为50%明显高于TS mRNA高表达组的25%(P<0.05),TS mRNA低表达组化疗后的平均生存时间为8.4个月,明显长于TS mRNA高表达组的3.5个月(P<0.05).DPD mRNA低表达组的S-1化疗有效率为42%,与DPD mRNA高表达组的33%相似(P>0.05).DPD mRNA低表达组的患者的总生存时间为6.5月,与DPD mRNA高表达组的7.2月相似(P>0.05).结论 外周血中TS mRNA高表达的患者对S-1治疗的有效率较低,生存时间较短,而DPD mRNA表达与S-1的疗效无显著相关性.%Objective The predictive values of TS and DPD mRNA in advanced gastric cancers treated with S-1. Methods The study population consisted of 24 patients with advanced gastric cancer. All of the patients treated by S-1 ,TS and DPD mRNA in pe ripheral blood were measured by the real time reverse transcription PCR(RT PCR) method. Results The response rate in the low TS mRNA group(25%) ,with significant difference(50%) was higher than that in the high TS mRNA group(25%) with signifi cant difference(P＜0. 05). Patients with low TS mRNA survived longer(8. 4 months) than those with high TS mRNA(3. 5 months) ,with significant difference(P＜0. 05). But there was no statistical difference in the response rates between low DPD mRNA group(42%) and high TS mRNA group(33%) ,with significant difference(P＜0. 05). There was no statistical difference(P＞ 0. 05) in the statistical survivals between low DPD mRNA group(6. 5 months) and high DPD mRNA group(7. 2 months). Conclusion The treatment effect of S-1 for advanced gastric cancer was negatively correlated with the status of TS mRNA, and there was no significant correlation between the treatment effect of S-1 and the status of DPD mRNA.
展开▼
