926例房颤患者抗栓治疗效果观察

摘要

Objective To observe the clinical efficacy of antithrombotic therapy applied in the patients with atrial fibrillation (AF). Methods 926 inpatients or outpatients with non-valvular AF from January 2008 to December 2011 were selected and divided into 3 groups according to the different antithrombotic therapeutic schemes. 329 cases as the warfarin group received warfarin treatment,oral warfarin 2. 5 mg per day,and timely adjusted the dose for reaching the international normalized ratio(INR) of 2 - 3. 299 cases as the aspirin group received aspirin treatment,oral aspirin 100 mg per day. And other 298 cases as the control group were given the routine treatment without any antithrombotic medication. The occurrence rates of ischemic stroke and bleeding events were compared among 3 groups. Results The occurrence rate of ischemic stroke in the warfarin group and the aspirin group was lower than that in the control group(P<0. 05) ,and compared with the aspirin group,the decrease in the warfarin group was more significant(P<0. 05). The occurrence rates of bleeding events had no statistical difference among 3 groups(P>0. 05). Conclusion Aspirin or warfarin therapy can obviously reduce the occurrence rate of ischemic stroke in the patients with AF,but the effect of warfarin is more remarkable.%目的 探讨对房颤患者抗栓治疗的效果.方法 选择2008年1月至2011年12月该院住院或门诊就诊的非瓣膜性房颤患者926例,按患者目前正在接受的抗栓治疗策略的不同进行分组,采用华法林抗栓治疗的329例为华法林组,每日口服华法林2.5 mg并适时调整剂量使国际标准化比值(international normalized ratio,INR)达到2～3;采用阿司匹林抗栓治疗的299例为阿司匹林组,每日口服阿司匹林100 mg;另298例仅接受常规治疗,未接受任何抗栓药物治疗的患者为对照组.比较各组患者缺血性脑卒中发生率和与抗栓治疗相关的出血事件发生率.结果 华法林和阿司匹林治疗后患者缺血性脑卒中发生率低于对照组(P<0.05);华法林组比阿司匹林组缺血性脑卒中的发生率降低更为显著(P<0.05);3组患者出血事件发生率比较差异无统计学意义(P>0.05).结论 阿司匹林或华法林治疗均能显著降低房颤患者缺血性脑卒中发生率,华法林的效果更为显著.