Objective To observe the expression of neuronal cadherin (N-cadherin) and vimentin in primary rectum adenocarci-noma tissues and their clinical value .Methods 58 cases of primary rectum adenocarcinoma tissues after surgical resection and con-firmed by pathology ,and normal rectum tissues that at lest 5 cm away from the tumor were selected .The immunohistochemical SP method was used to detect the expression of N-cadherin and vimentin and analyzed their correlation .Results In rectum adenocarci-noma tissues ,the positive expression rate of N-cadherin and vimentin[53 .4% (31/58) ,46 .6% (27/58)]were significantly higher than those of in normal rectum mucosa tissues[3 .4% (2/58) ,1 .7% (1/58)] ,(P<0 .01) .The expressions of N-cadherin and vimen-tin were positively correlated with the depth of cancer invasion ,lymph node metastasis ,distant metastasis and tumor-node-metasta-sis(TNM) stage(P<0 .05) ,but without correlated with the tumor cell differentiation(P>0 .05) .Conclusion N-cadherin and vim-entin have close relationships with metastasis of rectum adenocarcinoma ,to detect the expressions of N-cadherin and vimentin is of a effective method to judge the metastasis and prognosis of rectum adenocarcinoma .%目的：探讨N钙黏蛋白（neuronal cadherin ，N-cadherin）和波形蛋白（vimentin）在原发性直肠腺癌中的表达及其临床意义。方法选择手术切除并经病理证实的58例原发性直肠腺癌组织和距肿瘤5 cm以上的正常直肠黏膜组织，采用免疫组织化学SP法检测组织中N-cadherin和vimentin的表达并与临床资料进行相关性分析。结果直肠腺癌组织中N-cadherin和vim-entin阳性表达率[53．4％（31／58）、46．6％（27／58）]明显高于正常直肠黏膜组织[3．4％（2／58）、1．7％（1／58）]（P＜0．01）；N-cad-herin和vimentin的阳性率与肿瘤浸润深度、淋巴结转移、远处转移和 TNM 分期呈正相关（P＜0．05），与肿瘤分化程度无相关性（P＞0．05）。结论 N-cadherin和vimentin的表达与原发性直肠腺癌的转移密切相关，检测N-cadherin和vimentin的表达可作为判断直肠腺癌转移和预后的指标之一。
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