目的 研究抗精神病药物对精神分裂症患者肝肾功能的影响.方法 将64例精神分裂症患者根据病情要求分别给予氯丙嗪、奋乃静、利培酮,测定单药治疗前后8周的丙氨酸转氨酶、天冬氨酸转氨酶、总胆红素、直接胆红素、血清尿素氮、肌酐.结果 服用氯丙嗪、利培酮后,与用药前相比,丙氨酸转氨酶、天冬氨酸转氨酶差异有统计学意义(P＜0.05),奋乃静对肝功能指标的影响差异无统计学意义(P＞0.05),肝功能异常发生率为25%.结论 抗精神病药物可导致精神分裂症患者肝功能异常,在治疗精神分裂症患者期间应定期监测肝肾功能.%Objective To study the effects of antipsychoties on liver and renal functions in patients with schizophrenia. Methods A total of 64 patients with schizophrenia were allocated to receive chlorpromazine, perphenazine or risperidone according to their status. Serum levels of ALT, AST, TBIL, DBIL, BUN and Cr before and at 8 weeks after monotherapy were tested. Results Significant differences in serum ALT and AST between baseline and at 8 weeks and after monotherapy with chloropromazine or risperidone were observed (P＜0.05), while no statistical significance in perphenazine effect on liver function was noted (P＞0.05). Liver dysfunction was found in 25％ of the patients. Conclusion Antipsychotics may interfere with liver and renal functions, so that regular monitoring of liver and renal functions is recommended during antipsychotic treatment.
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