Disease biomarkers for schizophrenia reverted by anti-psychotic drug administration: six-plex quantitative phosphoproteomics of prefrontal cortex synaptosomes

摘要

Neuronal phosphorylation processes were identified as biomarkers in a schizophrenia disease model, and reverted after administration of anti-psychotic drugs. Large-scale multiplex quantitative phosphoproteomics where demonstrated suitable for disease biomarker discovery. Reversion of phosphorylationsites by antipsychotic treatment demonstrates their potential as biomarkers to monitor disease and drug efficacy. Both well-known and novel phoshopeptides were modulated in the schizophrenia disease model, and reverted in response to treatment e.g. proteins related to synaptic neurosignalling, neurogenesis, the glutamate receptor pathway and the neuronal cytoskeleton.