Wnt信号通路诱导肿瘤细胞上皮间质转化的研究进展

摘要

EMT in tumor cells favors their invasion and migration ( metastasis) , which is critical during the tumor progression. Wnt signaling pathway promotes and regulates many life proces -ses. As an important inducer of EMT, Wnt signaling pathway plays an extremely vital and irreplaceable role in inducing EMT. Meanwhile, EMT can be blocked and reversed with the regula-tion of Wnt signal molecules. It also enhances anti -tumor drugs development from a brand new perspective . This paper reviews the mechanism of Wnt signaling pathway in EMT .%肿瘤细胞发生上皮间质转化(epithelial-mesenchymal transition,EMT)从而具有侵袭转移的能力,是肿瘤发展的一个重要过程.既往研究发现Wnt信号通路调节控制着许多生命过程,也发现其是诱导EMT不可缺少的重要通路.通过对Wnt信号分子的调控,可以有效的阻断甚至逆转EMT.Wnt诱导EMT发生发展过程的研究,也为抗肿瘤新药开发提供了新思路,推动了药物的研发.该文旨在对近年Wnt信号通路诱导EMT的研究做一综述.