香芹酚对STZ诱导的1型糖尿病小鼠糖脂代谢的影响

摘要

Aim Carvacrol ( CAR ) , possesses a wide variety of pharmacological properties including antioxi-dant and anti-inflammatory potential. The present stud-y is designed to investigate the effect of CAR on glu-cose and lipid metabolism in type 1 diabetic mice. Methods Diabetes was induced by intraperitoneal( i. p) injection of streptozotocin into male mice at the dose of 45 mg·kg-1 body weight( BW) . Mice were divided into three different groups containing eight to twelve in each. Age matched male C57 mice were used as nor-mal controls. Group I diabetes, Group Ⅱ and Ⅱ in-jected with CAR at 10 and 20 mg · kg-1 BW respec-tively once daily. After CAR injection 2, 4 or 6 weeks, the rats were weighted and the plasma concen-trations of glucose, total cholesterol( TC) , triglycerides (TG), Glutamic oxalacetic transaminase(AST), Ala-nine transaminase( ALT) levels were enzymatically de-termined using commercial kits. Results STZ-induced C57 BL/6 J diabetic mice showed an elevation in serum glucose, TG, ALT, AST and LDH levels. Compared to diabetic mice, administration of CAR resulted in sig-nificant decreases(P <0. 05) in plasma glucose, TG and LDH levels in a dose dependent manner, but no effect on elevated TC, ALT and AST levels. Conclu-sion These major findings provide evidence that CAR has anti diabetic property and it has the potential for development into a drug to prevent hyperglycemia, re-duce blood lipids and protect the dammaged organs.%目的观察香芹酚对糖尿病小鼠糖脂代谢的影响。方法腹腔注射链脲佐菌素( streptozotocin,STZ)建立1型糖尿病C57BL/6小鼠模型,成模小鼠随机分成3组(糖尿病组、香芹酚10、20 mg·kg-1低、高剂量组),以同周龄同性别正常小鼠为对照组。糖尿病组和对照组腹腔注射生理盐水,其余组每天腹腔注射香芹酚,每周测体重和随机血糖,分别在给药2、4、6周后处死,收集小鼠血清,检测血糖、血脂、血总胆固醇、肝功能指标。结果香芹酚可有效降低糖尿病小鼠的随机血糖、血脂和乳酸脱氢酶水平。结论香芹酚可降低1型糖尿病小鼠血糖、血脂,保护受损器官,对糖尿病及其并发症有一定的治疗作用。