Mitochondria is an important organelle in mammalian cells with multiple functions,such as ener-gy production and cell homeostasis maintaining. It is known that hundreds of diseases are associated with mi-tochondrial defects. The studies show that the exoge-nous mitochondria can directly enter mammalian cells in vitro, and they also can quickly transform into ani-mal tissues by local or intravenous injection. Current-ly, it has raised a new therapeutic strategy for mito-chondrial diseases, called mitotherapy, which trans-plants exogenous functional mitochondria into mito-chondria-defective cells. The mitochondria in recipient cells play their own roles, including energy produc-tion,maintaining free radical balance,and cell viabili-ty recovery. Since there is no effective method for mito-chondria-related diseases up to now, the mitotherapy will provide a new approach for the prevention and treatment of these diseases.%线粒体是哺乳动物细胞中供应能量、维持胞内稳态等多种功能的细胞器.目前已知有上百种疾病与线粒体功能缺陷有关.研究表明,外源线粒体可直接进入哺乳动物细胞,并可通过局部注射或静脉注射快速转移到动物或人体细胞内.线粒体治疗(mitotherapy)是通过将正常有功能的线粒体移植到具有线粒体缺陷的细胞中,从而对相关疾病进行防治的新策略.移植的线粒体在受体细胞内可发挥能量生成、维持自由基平衡、恢复细胞活力等功能.由于目前对线粒体相关疾病尚缺乏有效的治疗方法,线粒体治疗将为其防治提供一个新的途径.
展开▼
