茴香醛、茴香脑以及肉桂醛对5-氟脲嘧啶体外透皮吸收的影响

摘要

To investigate the effects of anisaldehyde,anethole and cinnamaldehyde on the in vitro percutaneous permeation of 5-fluorouracil (5-FU).METHOD:The percutaneous permeation of 5-FU was investigated in hairless mouse skin after application of cinnamaldehyde,anethole,or anisaldehyde with ethanol or propylene glycol (PG) using a diffusion cell technique.RESULT:The above volatile constituents (2%,w/v) in combination with 20% ethanol or 30% PG significantly increased the permeability coefficient of 5-FU (P<0.01) in comparison with the control.CONCLUSION:Anisaldehyde,anethole and cinnamaldehyde in combination with ethanol or propylene glycol can be used to enhance the percutaneous absorption of 5-FU.%目的:察茴香醛、茴香脑以及肉桂醛对5－氟脲嘧啶体外透皮吸收的影响.方法:用扩散池技术,裸鼠皮肤为实验材料,察5－氟脲嘧啶的透皮吸收情况.结果:上三种挥发性成分（2%，w/v）在联合使用20%乙醇或者30%丙二醇时,都可以显著提高5－氟脲嘧啶的透皮吸收系数（P<0.01）.论:香醛、茴香脑和肉桂醛联合使用乙醇或者丙二醇可以用于促进5－氟脲嘧啶的透皮吸收.