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5-氟脲嘧啶

5-氟脲嘧啶的相关文献在1989年到2022年内共计684篇,主要集中在肿瘤学、药学、皮肤病学与性病学 等领域,其中期刊论文660篇、会议论文24篇、专利文献134579篇;相关期刊352种,包括实用临床医药杂志、临床肿瘤学杂志、现代肿瘤医学等; 相关会议17种,包括第五届国际中医、中西医结合肿瘤学术交流大会暨第十四届全国中西医结合肿瘤学术大会、中华护理学会护理学术年会、全国护理管理改革创新高层论坛暨全国护理新理论、新方法、新技术研讨会、中华医学会第十八次全国高压氧医学学术会议等;5-氟脲嘧啶的相关文献由1714位作者贡献,包括卓仁禧、孙昌俊、等等。

5-氟脲嘧啶—发文量

期刊论文>

论文:660 占比:0.49%

会议论文>

论文:24 占比:0.02%

专利文献>

论文:134579 占比:99.49%

总计:135263篇

5-氟脲嘧啶—发文趋势图

5-氟脲嘧啶

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  • 卓仁禧
  • 孙昌俊
  • 平其能
  • 李金运
  • 刘魁凤
  • 丁颖
  • 井欢
  • 关洪全
  • 刘树权
  • 期刊论文
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    • 韩成龙; 李苏阳; 韩雅萌
    • 摘要: 目的研究丹皮酚对5-氟尿嘧啶(5-FU)诱导小鼠肠黏膜损伤中的保护作用。方法SD成年雄性C57BL/6J小鼠随机分为对照组(Con组,12只)、5-FU注射组(5-FU组,12只)、丹皮酚25 mg/kg组(5-FU+Pae 25 mg/kg组,13只)、丹皮酚100 mg/kg组(5-FU+Pae 100 mg/kg组,13只)。通过腹腔注射5-FU建立小鼠肠黏膜损伤模型,探讨丹皮酚对小鼠5-FU注射后体重的影响。HE染色观察丹皮酚对小鼠小肠绒毛损伤的形态学影响;免疫组化实验研究小鼠小肠腺细胞凋亡情况;成瘤实验观察丹皮酚对5-FU抗肿瘤活性的影响。结果注射5-FU 9天后,小鼠体重显著降低,而丹皮酚处理后可显著恢复小鼠体重。丹皮酚可明显降低小肠水肿程度或出血,并使小肠绒毛升高,增加小肠腺细胞数量。免疫组化结果显示,丹皮酚可显著降低小肠腺细胞凋亡程度。结论丹皮酚可通过抑制小肠腺细胞凋亡降低5-FU对小鼠黏膜损伤的影响,具有一定的抗肿瘤作用,并可增强其抗肿瘤活性。
    • 摘要: 1、老年斑如果数量很少,可以采取冷冻或激光法,可色斑数目较多时,宜用5氟脲嘧啶软膏外用,或采用经验方法,每日3次拍打手背,拍打到发红发热,再摩擦100次,大约两三个月可使老年斑自行消失。2、生姜中含有多种活性成分,其中的姜辣素有很强的对抗脂褐素的作用。
    • 王彦茹; 赵艳杰; 林素兰; 郑玉建
    • 摘要: 目的 研究抑制黏着斑激酶(FAK)-蛋白激酶B(Akt)信号通路活化在减轻中心静脉导管(CVC)联合5-氟脲嘧啶(5-FU)诱导的血管内皮细胞氧化性损伤中的作用及其机制.方法 将EA.hy926细胞随机分为3组:正常组、模型组和实验组,每组3个时间点:24,48,72 h,每个时间点8个复孔.模型组(CVCs+划痕+5-FU),细胞划痕后,放入截好的CVC节段3个,再加入5-FU(40μg·mL-1),建立EA.hy926细胞氧化损伤模型;实验组在模型组基础上加入FAK抑制剂(Y15,50μmol·L-1).以噻唑蓝比色法检测各时间点(24,48,72 h)细胞活性(OD值),以2,7-二乙酸二氯荧光素检测细胞活性氧(ROS)水平,硝酸还原酶法测定细胞培养液中一氧化氮(NO)含量,以蛋白质印迹法检测细胞中p-FAK Tyr 397和p-Akt Ser 473的表达水平(灰度值).结果 干预72 h后,正常组、模型组和实验组的细胞存活率分别为(94.80±3.27)%,(50.20±3.96)% 和(71.00±2.92)%;这3组的ROS相对水平分别为(98.82±6.63)%,(469.83±19.60)%和(178.01±11.49)%;这3组的NO含量分别为(59.33±2.44),(22.10±2.57)和(43.39±2.58)μmol·L-1;这3组的p-FAK Tyr 397相对表达水平为0.19±0.02,1.27±0.04和0.88±0.01;这3组的p-Akt Ser 473相对表达水平为0.14±0.02,1.17±0.04和1.05±0.09.上述指标:正常组与模型组比较、或实验组与模型组相比,差异均有统计学意义(P<0.01或P<0.001).结论 抑制黏着斑激酶-蛋白激酶B信号通路活化能够减轻CVC联合5-FU诱导的EA.hy926细胞氧化损伤.
    • 陈莉
    • 摘要: Objective To explore the effect of serum MACC1 on forecasting chemotherapeutic effect of patients with gastric cancer.Methods The difference in sensitivity of BCG-823 to 5-fluorouracil (5-Fu) between gastric cancer cell line BCG-823 with over-expression and low expression of MACC1 was detected by MTT method.The expression of MACC1 mRNA in gastric cancer cells with over-expression and low expression was detected by RT-PCR.ELISA was used to detect the expression of MACC1 protein in MACC1 over-expressed and low expression cells.Relationship between the expression of MACC1 in peripheral blood before chemotherapy and the effect of chemotherapy in patients with advanced gastric cancer was analyzed.Results The mRNA expression level of MACC1 decreased after MACC1 silencing and increased after MACCI over-expression,which were consistent with the tendency of protein expression level.After interfering with MACC1,the sensitivity of BCG-823 to 5-Fu increased,and the sensitivity to 5-Fu reduced after over-expression of MACC1.The patients with low contents of serum MACC1 showed prior chemotherapeutic effect to those with high contents of MACC1.Conclusion MACC1 can be used as a useful biomarker for forecasting the efficacy of chemotherapy in patients with gastric cancer.%目的 探讨血清结肠癌转移相关基因-1(MACC1)对胃癌患者化疗疗效的预测作用.方法 MTT法检测MACC1过表达、低表达的胃癌细胞株BCG-823对5-氟脲嘧啶(5-Fu)敏感性的差异.RT-PCR检测MACC1过表达、低表达的胃癌细胞中MACC1 mRNA表达水平.ELISA法检测MACC1过表达、低表达细胞培养液中MACC1蛋白表达水平.分析晚期胃癌患者化疗前外周血中MACC1表达水平与化疗疗效的关系.结果 干扰MACC1后,BCG-823细胞中mRNA表达水平下降,过表达细胞中的mRNA表达水平上升,其趋势与细胞培养液中MACC1蛋白表达水平一致.干扰MACC1后,BCG-823对5-Fu敏感性增高,过表达MACC1后其对5-Fu敏感性降低.晚期胃癌患者MACC1蛋白含量较低的患者化疗疗效好于MACC1含量较高的患者.结论 MACC1能够影响胃癌病人对化疗的敏感性,可以有效预测患者化疗疗效.
    • 张定国; 阮建; 阮秀丽
    • 摘要: 目的 探讨卡培他滨+奥沙利铂(XELOX)化疗方案与亚叶酸钙/5-氟脲嘧啶+奥沙利铂(FOLFOX6)化疗方案治疗晚期结直肠癌的近期疗效、不良反应及远期生存率的影响.方法 选取106例晚期结直肠癌患者为研究对象,其中接受XELOX化疗方案者57例,接受FOLFOX6方案者49例.对比2组治疗总疗效、不良反应发生情况以及生存率.结果 治疗后,XELOX组总有效率为56.14%,FOLFOX6组总有效率为53.06%,2组差异无统计学意义(P>0.05).XELOX化疗组手足综合征发生率为14.04%,明显高于FOLFOX6化疗组发生率2.04%,差异有统计学意义(P0.05).XELOX组疾病无进展生存时间中位数为15个月,FOLFOX6组17个月;XELOX化疗组1年生存率为85.96%,高于FOLFOX6化疗组1年生存率83.67%,但差异无统计学意义(P>0.05).结论 XELOX与FOLFOX6化疗方案治疗晚期结直肠癌的疗效相当,但XELOX化疗方案用药更为安全方便.%Objective To investigate the effect of XELOX chemotherapy regimen and FOLFOX 6 chemotherapy regimen on short-term efficacy,adverse reaction and long-term survival rate in patients with advanced colorectal cancer.Methods 106 patients with advanced colorectal cancer were selected as the study subjects,including 57 patients received XELOX chemotherapy regimen,49 patients received FOLFOX6 regimen.Comparison of the total treatment of two groups,the incidence of adverse reac-tions and survival rate.Results After treatment,the total effective rate of XELOX group was 56.14%,the total effective rate of FOLFOX6 group was 53.06%,and the difference was not statistically significant(P>0.05);The incidence of hand-foot syn-drome in XELOX chemotherapy group was 14.04%,which was significantly higher than that in FOLFOX 6 chemotherapy group (2.04%),the difference was statistically significant(P0.05).The median survival time of non-progression of XE-LOX group was 15 months,FOLFOX6 group was 17 months;The 1-year survival rate was 85.96%in the XELOX chemotherapy group,which was higher than that in the FOLFOX6 chemotherapy group(83.67%),but the difference was not statistically signifi-cant(P>0.05).Conclusion XELOX and FOLFOX6 chemotherapy in the treatment of advanced colorectal cancer have the same effect,but XELOX program more secure and convenient.
    • 胡宏玲; 何玲
    • 摘要: 目的 观察5-氟脲嘧啶湿敷联合红光治疗尿道口尖锐湿疣的疗效.方法 按随机数字表将65例患者分为对照组30例和观察组35例.对照组采取CO2激光治疗及护理,观察组采取5-氟脲嘧啶湿敷联合红光治疗及护理.观察治疗6个月后患者临床疗效及不良反应.结果 观察组的痊愈率为91.4%、对照组痊愈率为66.7%,经比较,差异有显著性意义(P<0.05);观察组治疗不良反应发生率低于对照组,经比较,x2=18.73,P<0.01.结论 5-氟脲嘧啶湿敷联合红光治疗尿道口尖锐湿疣效果较好.
    • 顾小丽
    • 摘要: 目的:观察CO_2激光、5-氟脲嘧啶、消疣汤联合治疗复发性尖锐湿疣(CA)的效果。方法:92例随机分为治疗组和对照组各46例,治疗组用CO_2激光、5-氟脲嘧啶软膏与消疣汤联合治疗,对照组仅用CO_2激光和5-氟脲嘧啶软膏治疗。结果:治疗组复发率低于对照组(P<0.05)。结论:综合疗法治疗复发性尖锐湿疣复发率低。
    • 杨耀群; 谢淑丽; 吕国悦; 马强; 李开良; 王广义
    • 摘要: Objective:To investigate the influence of P27RF-Rho mRNA gene silencing in the drug sensitivity of 5-fluorouracil(5-Fu)to the liver cancer SMMC cell line,and to provide theoretical basis for the treatment of advanced liver cancer.Methods:The P27RF-Rho RNAi vector was constructed and the P27RF-Rho gene silencing lentivirus were used to infect the SMMC7721 cells.Western blotting method was used to detect the gene silencing effect.The SMMC7721 cells were divided into Scramble-siRNA group, 5-Fu group, P27RF-Rho siRNA group and P27RF-Rho siRNA + 5-Fu group.Western blotting was used to detect the transfection efficiency of RNAi.MTT method was used to detect the cell growth in various groups.Scratching test was used to detect the migration ability of cells in various groups.Transwell experiment were used to detect the invasion ability of cells in various groups.The expressions of P27 and RhoC protein were detected by Western blotting method.Results:P27RF-Rho RNAi lentiviral vector was successfully constructed.The Western blotting results showed that the expression of P27RF-Rho protein in P27RF-Rho siRNA group was decreased compared with 5-Fu group and Scramble-siRNA group(P<0.05).Compared with other three groups, the growth speed of the cells in P27RF-Rho siRNA + 5-Fu group was significantly decreased(P<0.05).The migration ability of the cells in P27RF-Rho siRNA + 5-Fu group was significantly lower than those in other three groups (P<0.01);the average number of cells passing through the Transwell microporous membrane was significantly less than those in other three groups (P<0.01).The Western blotting analysis results showed that the expression level of P27 protein in the cells in P27RF-Rho siRNA + 5-Fu group was significantly higher than those in other three groups(P<0.05);the expression level of RhoC protein was significantly lower than those in other three groups(P<0.05).Conclusion:P27RF-Rho gene silencing can significantly enhance the drug sensitivity of 5-Fu to SMMC7721 cells.%目的:探讨肝癌SMMC7721细胞株P27RF-Rho mRNA基因沉默对5-氟脲嘧啶(5-Fu)药物敏感性的影响,为临床晚期肝癌治疗提供理论依据.方法:构建P27RF-Rho RNAi载体,P27RF-Rho基因沉默慢病毒感染SMMC7721肝癌细胞,Western blotting法检测基因沉默效果.SMMC7721细胞分为Scramble-siRNA阴性对照组、5-Fu组、P27RF-Rho-siRNA组和P27RF-Rho-siRNA+5-Fu组.荧光显微镜检测细胞转染效果,Western blottting法检测RNAi基因沉默效率,MTT法检测各组细胞生长曲线,划痕实验检测细胞迁移能力,Transwell小室检测细胞侵袭能力,Western blotting法检测各组细胞中肿瘤相关蛋白P27及RhoC表达.结果:成功构建P27RF-Rho RNAi慢病毒载体.Western blotting法,P27RF-Rho-siRNA组细胞中P27RF-Rho蛋白表达水平明显低于5-Fu组和Scramble-siRNA组(P<0.05).与其他3组比较,P27RF-Rho-siRNA+5-Fu组细胞生长速度降低(P<0.05);划痕实验中P27RF-Rho-siRNA+5-Fu组细胞迁移能力明显减低(P<0.01);P27RF-Rho-siRNA+5-Fu组穿过Transwell小室微孔滤膜的平均细胞数明显少于其他3组(P<0.01);Western blotting法检测,P27RF-Rho-siRNA+5-Fu组细胞中癌相关蛋白P27表达水平明显高于其他3组(P<0.05),侵袭相关蛋白RhoC表达水平低于其他3组(P<0.05).结论:P27RF-Rho基因沉默能明显增强5-Fu对肝癌SMMC7721细胞的药物敏感性.
    • 李进科; 付建军; 张永国; 李智斌
    • 摘要: 目的 探讨大肠癌患者肿瘤组织中胸苷酸合成酶(TS)表达水平及对预后的影响.方法 选择80例大肠癌患者的肿瘤组织标本和癌旁组织标本作为研究材料,应用免疫组化法对标本中的TS表达水平进行检测和比较;对患者的性别、年龄、浸润深度、分期、分化程度、5年生存率、总生存期(OS)、无病生存期(DFS)等指标及影响因素进行比较.结果 肿瘤组织标本中的TS高表达比例显著高于癌旁组织标本(x2=76.201,P<0.05);TS高表达患者和TS低表达患者在性别构成、年龄、肿瘤浸润深度、肿瘤分期、肿瘤原发部位、肿瘤分化程度等一般临床资料的差异均无统计学意义(P>0.05);TS高表达患者与TS低表达患者的5年生存率、OS、DFS的差异均无统计学意义(x2=2.390、0.928、1.035,P>0.05);COX多因素回归结果显示,Dukes'分期与患者的OS(RH=2.813)和DFS(RH=4.516)具有相关性(P<0.05),而TS表达水平及其他临床指标与患者的OS和DFS均无相关性(P>0.05).结论 大肠癌组织呈现TS的高表达状态,但是大肠癌组织中的TS表达水平与患者的临床指标无显著相关性,也不会对患者的预后产生显著的影响.
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