Objective To investigate the clinical significance of combined detection of serum golgi protein 73 (GP73) and alpha fetoprotein (AFP) in the diagnosis of primary liver cancer (PLC). Methods A total of 568 serum cases were collected, including 192 cases of PLC, 256 cases of chronic hepatitis and cirrhosis (CH/LC) , and 120 cases of healthy control. The level of GP73 in each group was detected by enzyme-linked immunosorbent assay. The level of AFP in serum was detected by electrochemiluminescence. The data were then statistically analyzed. Results The serum level of GP73 and AFP in PLC group was significantly higher than that in CH/LC and normal control group (P ＜ 0.05) , and the serum level of GP73 and AFP in CH/LC group was significantly higher than that in normal control group (P ＜ 0.05). The sensitivity and specificity of GP73 in the PLC group were 61.45％ and 81.68％, respectively. The sensitivity and specificity of AFP in the PLC group were 42.19％ and 70.64％, respectively. The sensitivity and specificity of GP73 and AFP combination detection in the PLC group were 88.28％ and 43.16％, respectively. Conclusion Combination detection of serum GP73 and AFP can effectively improve the diagnostic efficiency of PLC, and may be used for the screening of high-risk group of PLC.%目的 探讨血清高尔基体蛋白73 (GP73) 和甲胎蛋白 (AFP) 联合检测对原发性肝癌 (PLC) 诊断的临床价值.方法 收集568例血清, 其中原发性肝癌192例, 慢性肝炎和肝硬化 (CH/LC) 患者256例, 健康对照120例, 采用酶联免疫吸附法检测各组GP73的水平, 采用电化学发光法检测血清中AFP的水平, 然后进行统计分析.结果 PLC组与CH/LC组和正常对照组的GP73含量和AFP含量的差异有统计学意义 (P ＜0.05) , GP73在PLC组的敏感性和特异性分别为61.45％和81.68％, AFP在PLC组的敏感性与特异性分别为42.19％和70.64％.GP73和AFP联合检测时敏感性与特异性分别为88.28％和43.16％.结论 血清GP73联合AFP检测能够有效地提高PLC的诊断效率, 可用于PLC高危人群的普查.
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