胎盘生长因子与胎儿生长受限的相关性研究

摘要

目的 探讨胎盘生长因子与胎儿生长受限的相关性.方法 采用放射免疫法测定17例胎儿生长受限孕妇(研究组)和20例正常孕妇(对照组)的血清及新生儿脐血胎盘生长因子水平,并对其结果进行相关性研究.结果 研究组孕妇血清胎盘生长因子(38.12±0.91ng/L)低于对照组(40.41±1.77ng/L),差异有统计学意义(t=6.74,P<0.05);研究组新生儿脐血胎盘生长因子(38.35±1.10ng/L)低于对照组(40.45±1.46ng/L),差异有统计学意义(t=2.35,P<0.05).孕妇血清胎盘生长因子水平与新生儿脐血胎盘生长因子水平无相关性(r=0.120,P>0.05),孕妇血清胎盘生长因子水平与新生儿出生体重无相关性(r=0.005,P>0.05).新生儿脐血胎盘生长因子水平与新生儿出生体重呈正相关(r=0.430,P<0.01).结论 胎盘生长因子可能在胎儿生长受限的发病中有重要的作用,并可能为将来诊断和治疗胎儿生长受限提供新的途径.%Objective To explore the relationship between the level of placenta growth factor ( PLGF ) and the pathogenesis of fetal growth restriction ( FGR ). Methods Inmunoradioassay was used to measure the PLGF level of serum and cord blood in 17 pregnant women with FGR ( FGR group ) and 20 normal pregnant women ( control group ), and the results in both groups were analyzed. Results PLGF of the maternal serum in FGR group ( 38.12 ±0.91ng/L ) was significantly lower than that in the control group ( 40.41 ± 1.77ng/L ) ( t ＝6.74,P ＜ 0.05 ), and PLGF of the umbilical serum in FGR group ( 38.35 ± 1.10ng/L ) was also significantly lower than that in the control group ( 40.45 ± 1.46ng/L ) ( t＝ 2.35, P ＜ 0.05 ). The maternal serum PLGF was not correlated with that of the umbilical serum( r＝ 0. 120, P ＞ 0.05 ). It was not correlated with newborn birth weight ( r＝ 0.005, P ＞ 0.05 ). PLGF of umbilical serum was positively related with neonatal weight ( r ＝0.430, P ＜0.01 ). Conclusion The change of PLGF level may play an important role in the pathogenesis of FGR,and PLGF may provide a new direction for diagnosis and treatment of FGR.