目的探讨乙肝病毒载量与妊娠期糖尿病的相关性。方法选取2011年1月1日到2012年12月31日来石家庄市妇幼保健院进行分娩的产妇13565例，其中按照是否携带乙肝病毒将其分为未携带乙肝病毒（ A）组10641例和携带乙肝病毒（B）组2924例。在B组中，再按照HBV-DNA的载量不同分为HBV-DNA含量阳性（B1）组（≥5×102IU/mL）及HBV-DNA含量阴性（B2）组（＜5×102IU/mL），对比A、B两组的妊娠期糖尿病发生率，及B1、B2两组的妊娠期糖尿病发生率。结果 B组妊娠期糖尿病的发生率为10．29％（301/2924）、A组妊娠期糖尿病的发生率为0．96％（102/10641），B组妊娠期糖尿病妊娠期糖尿病的发生率显著大于A组（χ2＝369．990，P＜0．05）；而B1、B2两组妊娠期糖尿病的发生率比较差异无统计学意义（ z＝0．296，P＞0．05）。结论乙肝病毒携带与妊娠期糖尿病的发生有关，乙肝病毒载量与妊娠期糖尿病的发生无性。%Objective To discuss the correlation between hepatitis B viral load and gestational diabetes mellitus (GDM).Methods From January 1 in 2011 to December 31 in 2012, totally 13 565 pregnant women who hospitalized in Maternal and Child Care Service Center of Shijiazhuang City for delivery were divided into non-hepatitis B virus group ( group A ) and hepatitis B virus group ( group B ) . There were 10 641 cases in group A and 2 924 cases in group B.Group B was further divided into group B1, namely HBV-DNA content positive group(≥5 ×102IU/mL) and group B2, namely HBV-DNA content negative group ( <5 ×102IU/mL).The incidence rate of GDM was compared between group A and group B , as well as group B1 and group B2.Results The incidence rate of GDM in group B and group A was 10.29%(301/2 924) and 2.36%(251/10 641), respectively, and it was significantly higher in group B (χ2 =369.990, P<0.05).However, the difference in the incidence rate of GDM between group B1 and group B2 was not significant(z=0.296, P=0.852>0.05).Conclusion Carrier of hepatitis B virus has significant correlation with GDM , while hepatitis B viral load has no close correlation with GDM .
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