Objective To explore and analyze the correlation between the ratio of peak systolic velocity to diastolic flow velocity ( S/D) of umbilical artery blood of pregnant women with gestational diabetes and fetal distress in uterus .Methods A total of 65 pregnant women with gestational diabetes were chosen in diabetes group , who received treatments in the First Hospital of Fangshan District from September 2013 to September 2015.Another 66 healthy pregnant women who underwent routine physical examinations in the hospital over the same period were chosen in non-diabetic group .S/D ratio of umbilical artery blood of fetuses at gestational age of 37 weeks was measured by color Doppler ultrasound .Mean value of S/D of umbilical artery blood of fetuses in both groups was compared .In addition , analysis of the correlation between changes in S/D value and fetal distress in uterus was carried out .Results Mean value of S/D of umbilical artery blood was significantly higher in diabetes group than that in non -diabetic group (t=4.32, P<0.05).Statistically significant differences were identified in the incidence rate of fetal distress in uterus between fetuses of different ranges of S /D value of umbilical artery blood in both groups (t value was 4.01, 4.11, 4.32, 4.17, 4.53 and 4.22, respectively, all P<0.05).When S/D value was greater than or equal to 2.71 but lower than 2.81 and when it was greater than or equal to 2.81 but less than 2.91, the differences in the incidence rate of fetal distress between diabetes group and non-diabetic group were most significant (t value was 4.17 and 4.53, respectively, both P<0.05). There was a significant correlation betweenS/D ratio of umbilical artery blood and the incidence of fetal distress in both groups ( r value was 0.984 and 0.976, respectively, both P<0.05).Conclusion The overall S/D value of umbilical artery blood and incidence rate of fetal distress in uterus in pregnant women with gestational diabetes are significantly higher than those of the pregnant women without gestational diabetes.When the S/D value of umbilical artery blood of pregnant women with gestational diabetes is higher than 2.71, the incidence rate of fetal distress increases significantly , and there is a positive correlation between the incidence rate of fetal distress and S /D value.In clinics, fetal distress can be predicted and controlled at early stage by measuring S /D value of umbilical artery blood in pregnant women with gestational diabetes .%目的：研究妊娠糖尿病孕妇胎儿脐动脉频谱血流收缩期最大血流速度与舒张期血流速度的比值（ S／D）与胎儿宫内窘迫的相关性。方法选取北京市房山区第一医院自2013年9月至2015年9月收治的65例妊娠糖尿病孕妇为糖尿病组，另选择同时期行常规体检的正常孕妇66例为非糖尿病组，用彩超测定37孕周时胎儿脐动脉血流频谱S／D值，比较两组胎儿脐动脉血流频谱S／D均值、脐动脉血流S／D值变化情况及其与胎儿宫内窘迫发生的相关性。结果糖尿病组胎儿脐动脉血流频谱S／D均值明显高于非糖尿病组（t＝4．32，P＜0．05）。糖尿病组与非糖尿病组不同胎儿脐动脉血流频谱S／D值区间胎儿宫内窘迫率差异均有统计学意义（t值分别为4．01、4．11、4．32、4．17、4．53、4．22，均P＜0．05），其中以S／D值≥2．71而＜2．81以及S／D值≥2．81而＜2．91时，糖尿病组与非糖尿病组胎儿窘迫率比较差异最为显著（t值分别为4．17、4．53，均P＜0．05）。非糖尿病组与糖尿病组不同脐动脉血流频谱S／D值区间胎儿宫内窘迫率均具有显著相关性（r值分别为0．984、0．976，均P＜0．05）。结论妊娠期糖尿病孕妇胎儿脐动脉血流频谱S／D值总体水平高于非妊娠期糖尿病孕妇，其胎儿宫内窘迫发生率也明显高于非妊娠期糖尿病孕妇；妊娠期糖尿病孕妇胎儿脐动脉血流频谱S／D值高于2．71时，胎儿宫内窘迫发生率明显升高可通过检测妊娠期糖尿病孕妇胎儿脐动脉血流频谱S／D值，预测并早期干预胎儿窘迫及剖宫产的发生。
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