彩色多普勒超声联合超声造影对乳腺癌新辅助化疗效果的评价

摘要

Objective To explore the value of color Doppler flow imaging (CDFI) combined with contrast-enhanced ultrasonography (CEUS) in evaluating efficacy of neoadjuvant chemotherapy for breast cancer.Methods Totally 69 cases with breast cancer adopting preoperative neoadjuvant chemotherapy in Nanchong Central Hospital during October 2015 to May 2016 were selected.The CDFI and CEUS were performed before and after chemotherapy.The lesion size and CEUS region of interest (ROI) parameters of patients before and after chemotherapy were compared.Results After neoadjuvant chemotherapy,the measured value of length,width,thickness,area and volume of the tumor lesion were significantly reduced (t value was 10.422,8.163,1 1.697,18.027 and 25.638,respectively,all P ＜ 0.05).After neoadjuvant chemotherapy,the CDFI blood flow resistance index (RI) of the tumor lesion was significantly higher than that before (t =4.498,P ＜ 0.05).Vmax was significantly reduced after chemotherapy,(t =12.033,P ＜ 0.05).After neoadjuvant chemotherapy,arrival time (AT) of ROI parameters contrast agent and time to peak (TTP) were significantly increased compared to those before chemotherapy (t value was 3.021 and 6.395,respectively,both P ＜0.05).Peak intensity (PI) was significantly lower than that before chemotherapy (t =13.087,P ＜ 0.05).Conclusion CDFI combined with CEUS can better evaluate the effect of neoadjuvant chemotherapy in patients with breast cancer.%目的 探讨彩色多普勒超声(CDFI)联合超声造影(CEUS)对乳腺癌新辅助化疗效果的评价.方法 选取2015年10月至2016年5月在南充市中心医院实施术前新辅助化疗的69例乳腺癌患者,分别于化疗前、化疗结束后进行CDFI、CEUS检查,对比化疗前后患者的病灶大小、CEUS的感兴趣区(ROI)参数变化.结果 新辅助化疗结束后,患者肿瘤病灶的长、宽、厚、面积、体积测定值较化疗前均显著缩小(t值分别为10.422、8.163、11.697、18.027、25.638,均P＜0.05);新辅助化疗结束后,患者病灶CDFI血流阻力指数(RI)测定值较化疗前显著增大(t=4.498,P＜0.05),Vmax较化疗前显著减小(t=12.033,P＜0.05);新辅助化疗结束后,患者病灶ROI参数造影剂达到肿瘤的时间(AT)、达峰时间(TTP)测定值均较化疗前显著增大(t值分别为3.021、6.395,均P＜0.05),峰值强度(PI)较化疗前显著减小(t=13.087,P＜0.05).结论 CDFI联合CEUS能够更较好地评估乳腺癌患者新辅助化疗的效果.