高分子量脂联素、总脂联素及其比值与乳腺癌发病的关系

摘要

目的 探讨高分子量脂联素、总脂联素及其比值与乳腺癌发病的关系.方法 选择2016年5月至2017年1月间杭州市肿瘤医院肿瘤外科收治的102例乳腺癌患者作为观察组,选择同期行健康体检的60例健康女性作为对照组,检测两组患者高分子量脂联素、总脂联素及其比值,并进行乳腺癌发病单因素和多因素分析.结果 对照组高分子量脂联素、总脂联素及其比值均显著高于观察组,两组比较差异均有统计学意义(t值分别为6.371、5.763、4.971,均 P<0.05);年龄越大、绝经、有乳腺癌家族史、超重、服用避孕药人群乳腺癌患病率更高,比较差异有统计学意义(χ2值分别为11.125、10.408、47.883、7.000、16.235,均P<0.05);多因素Logistics回归分析显示绝经、家族史、BMI≥24kg/m2可显著增加乳腺癌发病(χ2值分别为14.824、7.726、76.540,均P<0.05),是乳腺癌发病的独立危险因素.高分子量脂联素、总脂联素及其比值与乳腺癌的发病无明显相关性,差异无统计学意义(P>0.05).结论 乳腺癌患者高分子量脂联素、总脂联素及其比值下降,其是否为乳腺癌发病的保护因素仍待进一步研究.对存在乳腺癌危险因素的人群,应重点进行筛查,以期做到早发现、早治疗.%Objective To investigate the relationship between plasma high molecular weight adiponectin,total adiponectin and its ratio and the incidence of breast cancer.Methods From May 2016 to January 2017 102 cases of breast cancer were selected as observation group.Sixty cases of healthy women undergoing physical examination at the same period were selected as control group.The plasma high molecular weight adiponectin,total adiponectin and its ratio were measured and univariate and multivariate analysis was conducted.Results The plasma high molecular weight adiponectin,total adiponectin and its ratio were significantly higher in the control group than those in the observation group,and there were significant differences between two groups(t value was 6.371,5.763 and 4.971,respectively,all P<0.05).The prevalence of breast cancer was higher among cases with greater age, menopause,family history of breast cancer,overweight,and oral contraceptive use,and the differences were significant(χ2value was 11.125,10.408,47.883,7.000 and 16.235,respectively,all P<0.05).Multivariate Logistics regression analysis revealed that menopause,family history of breast cancer and BMI≥24 kg/m2could significantly increase the incidence of breast cancer(χ2value was 14.824,7.726 and 76.540,respectively,all P<0.05),and they were the independent risk factors of breast cancer.There was no significant correlation between high molecular weight adiponectin,total adiponectin and their ratio with the incidence of breast cancer(P>0.05).Conclusion Further studies are needed to explore whether high molecular weight adiponectin,total adiponectin and its ratio are protected factors of breast cancer.For the population with risk factors of breast cancer,the screening should be carried out in order to make early detection and early treatment.