腹水量对卵巢癌治疗的预测价值研究

摘要

Objective To investigate the predictive value of ascites on prognosis of ovarian cancer.Methods From January 2010 to October 2012 totally 134 cases of ovarian cancer accepting treatment in Changxing Traditional Chinese Medicine Hospital were collected and divided into group A(volume of ascites≤200mL),group B(200mL< volume of ascites<1 003mL)and group C (volume of ascites≥1 003mL).Analysis was conducted on differences in clinical factors and 5-year survival rate among different groups.Results There were significant differences in age,FIGO stage,differentiation degree,pathological type,residual lesions and proportion of cases with clinical efficacy between group C and group B and A(χ2value ranged 7.289— 18.927,P<0.05).The FIGO stage,degree of differentiation,residual lesions and proportion of cases with clinical efficacy of patients of group B were significantly different from group A(χ2value was 17.335,9.467,7.921 and 8.775,respectively,all P< 0.05).Kaplan-Meier analysis showed that 5-year overall survival rate and 5-year progression-free survival rate in group C were significantly lower than those in group A and B(Log rank χ2value was 16.198 and 11.198,respectively,both P<0.05),and that there was statistically significant difference in FIGO stage,degree of differentiation,residual lesions,5-year overall survival rate and 5-year progression-free survival rate(Log rank χ2value was 20.143,8.091,11.865,7.998,10.143,12.091,13.885 and 8.912,respectively,all P<0.05).Conclusion When the volume of ascites is more than 1 003 mL,the prognosis of cases of ovarian cancer is poor,and large FIGO staging,low degree of differentiation and lesion of incomplete resection are the key factors that leads to the decrease of survival rate.%目的 探讨腹水量对卵巢癌治疗预后的预测价值.方法 收集2010年1月至2012年10月在浙江省长兴中医院接受治疗的卵巢癌患者134例,根据腹水量分为 A(腹水量≤200mL)、B组(200mL < 腹水量< 1003mL)及 C组(腹水量≥1003mL),分析不同组别临床因素差异及5年生存情况.结果 C组年龄、国际妇产科协议(FIGO)分期、分化程度、病理类型、残留病灶、临床疗效患者比例与A、B组比较,差异有统计学意义(χ2=7.289~18.927,均 P<0.05),B组FIGO分期、分化程度、残留病灶及临床疗效患者比例与A组比较,差异有统计学意义(χ2值分别为17.335、9.467、7.921、8.775,均 P<0.05).Kaplan-M eier法分析显示,C组5年总生存率及5年内疾病无进展生存率低于A、B组(Log rank χ2值分别为16.198、11.198,均 P<0.05);不同FIGO分期、分化程度、残留病灶及临床疗效5年总生存率及5年内疾病无进展生存率存在统计学差异(Log rank χ2值分别为20.143、8.091、11.865、7.998、10.143、12.091、13.885、8.912,均 P<0.05).结论 当腹水量≥1003mL时卵巢癌患者预后差,FIGO分期大、分化程度低、病灶切除不完全是进一步导致生存率降低的关键因素.