BACKGROUND: Wnt signaling pathway regulates the balance of chondrocytes and osteoblasts, chondrocyte proliferation, ossification and degeneration in the degenerative changes of articular cartilage. It has been paid more and more attention. OBJECTIVE: To summarize the role of Wnt signaling pathway in osteoarthritis.METHODS: A computer-based online search of Wanfang and PubMed databases was performed for related articles published between 2001 and 2011, using key words of "Wnt, pathway, chondrocyte" in Chinese and English, respectively. A total of 24 articles in Wanfang database and 82 articles of PubMed database were collected, and 25 of them were retained according to inclusion criteria.RESULTS AND CONCLUSION: A series of proteins and their ligands in secretory Wnt family play an important role in chondrocyte ossification, osteoblast phenotype maintenance and the suppression of bone mesenchymal stem cells pimelosis. The classic Wnt/β-actnin signaling pathway participates in the regulation of osteoarthritis development by activating a series of signal molecules and inhibiting the cross and cascade reactions with other signaling pathways. Meanwhile, the molecules and their ligands in the Wnt signaling pathway are involved in the regulation of chondrocytes and osteoblasts balance, hyperosteogeny and bone reconstruction process.%背景:在关节软骨退行性病变中,Wnt信号通路在调节软骨细胞与成骨细胞的失衡,调控软骨细胞的增殖、骨化与退变的作用,越来越被人们所重视.目的:综述Wnt信号通路在骨性关节炎中的作用.方法:应用计算机检索万方数据库2001/2011相关文章,检索词为"Wnt,信号通路,软骨细胞",并限定文章语言种类为中文,共检索到文献24篇.同时计算机检索PubMed数据库2001/2011相关文章,检索词为"Wnt,pathway chondrocyte",并限定文章语言种类为English,共检索到文献82篇.最终纳入符合标准的文献25篇.结果与结论:分泌型Wnt家族中的一系列蛋白及其配体在软骨细胞骨化、成骨细胞表型维持、抑制骨髓间充质干细胞脂肪化等方面发挥着重要的作用.其经典的Wnt/β-actnin通路通过一系列信号分子的激活与抑制及与其他信号通路间的交叉和级联反应,参与调控骨性关节炎的发展进程.同时,Wnt通路中的分子及配体又参与调控成骨细胞与破骨细胞间转化的平衡、骨质增生与重建破坏等过程.
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