骨形态发生蛋白2信号通路与骨发生发育及损伤修复**★

摘要

背景：骨形态发生蛋白在骨形成过程中、骨折愈合后以及骨质破坏后骨诱导方面起着重要作用，它可以作为启动调节因子和别的信号通路共同促进新骨形成。内源性骨形态发生蛋白2的调节可以作为未来骨修复领域的一个新的靶点。目的：通过分析和总结1988年以来骨形态发生蛋白信号传导通路在软骨内成骨、维持成人骨骼生长发育中的作用机制，探索骨形态发生蛋白信号通路在骨的发育以及损伤修复中的作用。方法：分别以“骨形态发生蛋白、软骨内成骨、骨修复”，“bone reduction”为检索词，应用计算机检索重庆维普(VIP)期刊全文数据库及PubMed 数据库1998年1月至2009年12月有关文章。纳入有关骨形态发生蛋白信号通路及其作用的文献。排除与研究目的无关和内容重复者。保留34篇文献做进一步分析。结果与结论：骨形态发生蛋白信号通路诱导骨再生潜能在脊柱外科手术、骨折后愈合以及骨破坏后骨诱导等诸多领域成为研究热点。在骨形成过程中，骨形态发生蛋白也作为启动调节因子和别的信号通路相互影响共同促进新骨形成，出生后，骨形态发生蛋白也参与骨骼动态平衡的维持。在骨的微环境中，骨形态发生蛋白和其他影响骨质动态平衡的信号通路共同为诱导骨形成的合成代谢疗法提供了一个新靶点，这为骨修复时骨形态发生蛋白控制新骨的形成提供了一个新的思路。%BACKGROUND:Bone morphogenetic proteins play an important role in bone formation, fracture healing and bone induction after bone destruction, and it can be used as a start regulating factor to promote the new bone formation with other signal paths. The regulation of endogenous bone morphogenetic protein 2 can be used as a new target in the future field of bone repair. OBJECTIVE:Through analyzing and summarizing the mechanism of the bone morphogenetic protein signal transduction pathway in endochondral ossification reported from 1988 to now, adult bone growth and development, to explore the role of the bone morphogenetic protein signal pathways in the bone growth and damage repair. METHODS:A computer-based search was performed to search relevant articles about bone morphogenetic protein signaling pathways and its function from VIP and PubMed databases (1998-01/2009-12), respectively by using the key words of“bone morphogenetic protein, endochondral ossification, bone repair”in Chinese and“bone reduction”in English. Literatures irrelevant to research purpose or containing a similar content were eliminated. Final y, 34 articles were chosen for further analysis. RESULTS AND CONCLUSION:Because of its osteoinductive, bone morphogenetic protein signal pathway has become a hot spot in spinal surgery, fracture healing and bone induction after bone destruction. During the bone formation, the bone morphogenetic protein also serves as a start regulating factor to promote the new bone formation with other signal paths. In the bone micro environment, the bone morphogenetic protein and other signal paths that influence bone dynamic balance offer a new target for anabolic therapy that induces the bone formation, which provides a new thought on bone morphogenetic protein control to the formation of new bone fol owing bone repair.