背景：钛铌合金具有较高的生物力学强度及较低的弹性模量，更加接近于人皮质骨，目前已被广泛作为牙科、骨科及人工髋关节植入材料。 目的：观察不同孔隙率多孔钛铌合金的生物力学强度及细胞相容性。 方法：利用粉末冶金技术制备40%、70%孔隙率的多孔钛铌合金，检测两种多孔钛铌合金的孔径、弹性模量及抗压强度。将兔骨髓间充质干细胞分别接种于40%、70%孔隙率的多孔钛铌合金表面，接种3，24，72 h，观察细胞黏附与增殖情况。 结果与结论：①多孔钛铌合金孔径为200-500μm，两种均以350，400μm孔径为主，孔隙间三维连通，材料表面粗糙，70%孔隙率组孔隙呈蜂窝状，部分断裂，孔隙间连通；40%孔隙率组孔隙分布不均匀，孔隙间少有连通；两组钛铌合金均具有较高的抗压强度及较低的弹性模量，组间比较无差异；②两组钛铌合金均有利于细胞的黏附，70%孔隙率组表面的细胞黏附数量多于40%孔隙率组(P<0.05)，且70%孔隙率组表面可见细胞外基质已形成，结果表明70%孔隙率多孔钛铌合金更有利于细胞的黏附。%BACKGROUND:Titanium-niobium al oy holds high biomechanical strength and low elastic modulus that is close to the human cortical bone, so it has been extensively used as implant materials of dental, orthopedics and artificial hip joints. OBJECTIVE:To observe the biomechanical strength and cytocompatibility of porous titanium-niobium al oys with different porosities. METHODS:Porous titanium-niobium al oys with the porosity of 40%and 70%were prepared using powder metal urgy technology. Afterwards, the pore size, elasticity modulus and compressive strength of the two al oys were detected. Then the rabbit bone marrow mesenchymal stem cel s were seeded onto the 40%and 70%porous titanium-niobium al oys, and cel adhesion and proliferation were observed at 3, 24 and 72 hours after inoculation, respectively. RESULTS AND CONCLUSION:Pore size of porous titanium-niobium al oys with rough surface was 200-500μm, and both main pore size was 350 and 400μm, and there was three-dimensional connectivity between the pores;in the 70%group, honeycombed pores were partly fractured, and connected mutual y;pores distributed unevenly and there was little communication between the pores in the 40%group. In addition, both groups had high compressive strength and low elastic modulus, but there was no difference between the two groups. Furthermore, both two al oys promoted cel adhesion, and the number of cel adhesion in the 70%group was significantly higher than that in the 40%group (P<0.05), and extracel ular matrix could be found in the 70%group. These results show that porous titanium-niobium al oy with the porosity of 70%is significantly conducive to cel adhesion.
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