目的 评价法舒地尔对糖尿病伴急性心肌梗死(acute myocardial infarction,AMI)患者溶栓后左心功能的影响和安全性.方法 以66例糖尿病AMI静脉溶栓后的患者为研究对象,随机分为法舒地尔治疗组和对照组各33例,两组均控制血糖,静脉溶栓治疗AMI,法舒地尔治疗组在标准用药基础上滴注法舒地尔60 mg/d,对照组采用丹参注射液滴注,测定治疗前后临床心功能分级、血压、心率、左心室功能及血糖、血脂水平.结果 两组治疗后左室舒张末期内径( LVEDd)、左室收缩末期内径(LVEDs)均减小(P＜0.05),左心室射血分数(LVEF)及心输出量(CO)、短轴缩短率(FS)均有提高(P ＜0.05或P＜0.01),心舒张功能改善(P＞0.05).结论 法舒地尔治疗糖尿病伴AMI患者心功能不全安全、有效,同时能改善糖代谢和血脂.%Objective To compare the effects of fasudil and dengshen injection on left ventricular ( LV) dysfunction in diabetic patients with acute myocardial infarction ( AMI). Methods 66 diabetic patients with AMI companied with left ventricular dysfunction were randomly divided to receive fasudil in a mean does of 60 mg,qd(n =33)for 2 weeks or dengshen injection in a mean does of 20 ml,qd(n = 33 ) for 2 weeks. Clinical characteristics, NYHA function class, LV ejection fraction and serum biochemical changes were observed before and after treatment. Results In both the active and control groups, NYHA function class was improved, the left ventricular end systolic and diastolic diameters were decreased (P <0. 05 ) and the LVEF,CO and FS were increased (P <0.05 or P<0.01). Conclusion Fasudil not only can improve the cardiac function of diabetic patients with AMI,it can also help on glucose metabolism and lipid control in these patients.
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