D 二聚体、降钙素原与晚期恶性肿瘤患者静脉血栓栓塞症的相关研究

摘要

Objective To investignate the correlation of D- dimer and Procalcitonin with in malignant patients complicated with venous thromboembolism(VTE). Methods One eighty-nine malignants were divid-ed into two groups:embolization group(31 cases with VTE) and non- embolization group(58 cases without VTE). The plasma D-dimer and Procalcitonin were tested in all patients in the first week. Results D-dimer and Procalcitonin in plasma of patients with VTE was more higher than patients without VTE,P < 0. 05. D-di-mer in the death patients with VTE was higer than the patients alive. D-dimer in the patients with pneumonia and chemotherapy was higher than without pneumonia and chemotheray. Conclusion D-dimer have diagnos-tic value for VTE in malignant patients. D-dimme and Procalcitonin have impotant clinical prognosis for VTE in malignant patients.%目的：探讨晚期恶性肿瘤患者静脉血栓栓塞症(VTE)与 D 二聚体(D- D)及降钙素原(PCT)的相关性。方法选取89晚期恶性肿瘤,根据其是否发生 VTE 分为两组,栓塞组31例,非栓塞组58例,所有患者入院后1周内检测血浆中 D-D 和 PCT 的含量。结果栓塞组的 D-D 明显高于非栓塞组,PCT 栓塞组高于非栓塞组,两组比较有显著性差异(P <0．05),栓塞组中死亡患者的 D-D 明显高于非死亡患者,但 PCT 无明显差异；在合并肺部感染及曾经化疗过的患者 D-D 明显高于无肺部感染及未化疗过的患者,在合并肺部感染的晚期肿瘤患者 PCT 明显高于无肺部感染的患者,两组比较有显著性差异(P <0．05)。结论血浆 D-D 对于晚期恶性肿瘤血栓栓塞症(VTE)有一定诊断价值；联合检查D-D、PCT 在晚期恶性肿瘤 VTE 患者预后判断方面有所裨益。