3-(3-吡啶基)-4-氨基-5-芳胺基-1,2,4-三唑的合成与表征

摘要

Using nicotinic acid and aryl amines as the base stock, 1-(3-pyridyl)-4-aryl thiosemicarbazides were prepared as results of multistep reactions. The ring-closure of 1-(3-pyridyl)-4-aryl thiosemicarbazides in the presence of hydrazine hydrate gave the title compounds 3-(3-pyridyl)-4-amino-5-arylamino-1,2,4-triazoles, whose structures have been established by elemental analysis, IR, 1H NMR and 13C NMR spectra.%以烟酸与芳胺为基本原料,经多步反应,制得1-烟酰基-4-芳基氨基硫脲;后者在水合肼存在下关环,合成了一系列新化合物3-(3-吡啶基)-4-氨基-5-芳胺基-1,2,4-三唑.化合物结构经元素分析、IR,1H NMR,13C NMR确证.