(1S,6R)-1-羟基-6-(1,3-苯并二硫-2-氧)-3,5-环维生素D2的合成

摘要

以VD2为原料制备了1α,25-二羟基维生素D3的重要中间体(1S,6R)-1-羟基-6-(1,3-苯并二硫-2-氧)-3,5-环维生素D2.其中BDT(1,3-苯并二硫-2-氧)基团的引入有利于共轭三烯系统的保护.%An important intermediate of 1α,25-dihydroxyvitamin D3, (1S,6R)-1-hydroxy-6-(1,3-benzodithiol-2-yloxy)-3,5-cyclovitamin D2, was prepared from VD2. The BDT(1,3-benzodithiol-2-yl) group conduced to the protection of the conjugated triene system.