Six 2-(2,2,3,3-tetramethylcyclopropyl) oxazolines(five of them were new compounds) were synthesized by intramolecular cyclic dehydration reaction of N-β-hydroxyl-alkyl amides, which were prepared by acylation of 2,2,3,3-tetramethylcyclopropylcarboxylic acid with chiral amino alcohols. The structures were characterized by 1H NMR, 13C NMR, IR and HR-MS.%2,2,3,3-四甲基环丙烷甲酸和手性氨基醇经酰化反应制得6个N-β羟基烷基酰胺(3a ~ 3f).以DDQ/PPh3为羟基活化剂,3a~3f经分子内脱水环合合成了6个2-(2,2,3,3-四甲基环丙基)噁唑啉,其结构经1H NMR,13C NMR,IR和HR-MS表征(其中5个为新化合物).
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