α-溴-4-羟基苯乙酮的合成方法改进

摘要

The key intermediate of Synephrine, 2-bromo-l-(4-hydroxyphenyl)ethanone, was synthesized from 1-(4-hydroxyphenyl) ethanone using Br2 as the brominating reagent by improvement method in yield of 64.7% with purity of 90.2%. The structure was confirmed by 1H NMR.%以对羟基苯乙酮为原料,Br2为溴化试剂,用改进方法合成了辛弗林的关键中间体——α-溴-4-羟基苯乙酮,收率64.7％,纯度90.2％,其结构经1H NMR确证.