（±）-N-叔丁氧羰基-3-乙基-戊氨酸的合成

摘要

5-(Pentan-3-ylidene)imidazolidine-2,4-dione(4) was obtained at 55℃for 6 h under the op-timized reaction conditions [ hydantoin 2 mmol, n (3-pentanone )∶n ( hydantoin ) =1.5, cholamine as base, pH 4].5-(Pentan-3-yl)imidazolidine-2,4-dione(5) was prepared with hydrogenation of 4 by 5%Pd/C.( ±)-N-Boc-3-ethyl-norvaline was synthesized by hydrolyzation of 5 in alkaline condition , and then N-Boc protection reaction .The structure was confirmed by 1 H NMR, 13 C NMR and HR-ESI-MS.%在最优反应条件[海因2 mmol， n（3-戊酮）∶n（海因）＝1．5，乙醇胺为碱，pH 4，于55℃反应6 h]下制得5-（1-乙基亚丙基）海因（4）；4用5％Pd／C催化加氢制得5-（3-戊基）海因（5）；5先在碱性条件下水解，再通过叔丁氧羰基保护氨基合成了（±）-N-叔丁氧羰基-3-乙基-戊氨酸，总收率43％，其结构经1 H NMR，13 C NMR 和HR-ESI-MS确证。