吲哚-3-乙醛酰胺类化合物的合成及生物活性研究进展

摘要

综述了吲哚-3-乙醛酰胺类化合物(ID)的合成及生物活性的研究进展.ID具有抗肿瘤、抗病毒、抗菌、抗炎、腺苷受体功能调节、缓解疼痛和抗类风湿关节炎等多种生物活性,在药物化学领域有广泛应用.ID的合成方法主要为:吲哚母核与乙酰氯在乙醚(或THF)中于室温反应1 h制得含草酰氯结构的中间体;中间体与取代胺基化合物和二异丙基胺乙基胺反应合成ID.并对ID未来的应用作了简要展望.%The synthesis and bioactivities of indole-3-glyoxylamide derivatives( ID) were reviewed with thirty two references. ID, which exhibited well bioactivities in antitumor, antivirus, antibacterial, anti-inflammatory, adenosine regulation, etc, were widely applied in pharmaceutical chemistry. The main method for synthesizing ID was as follows: the intermediate containing oxalyl chloride ( M ) was ob-tained by the reaction of indole nuclear parent with acetylchloride in diethyl ether( or THF) by reaction rt for 1h. ID were synthesized by the reaction of M with substituted amino compound and N,N-diiso-propylethylamine. The forecast of the application of ID was briefly proposed.