肝切除术后肝脏再生与肿瘤复发相关性的研究进展

摘要

Partial hepatectomy is still the preferred modality of treatment for hepatocellular carcinoma.In recent years,a substantial number of in vivo and in vitro tests have been carried out to study how to promote postoperative liver regeneration in order to prevent the occurrence of small-for-size liver syndrome and liver failure.However,several studies have shown that the process of liver regeneration after hepatectomy can actually promote the growth of tumor cells and activate occult micro-focal lesions leading to tumor recurrence.Moreover,cytokines and genes which play crucial roles in the 3 stages of liver regeneration,are involved in the formation,migration,infiltration and recurrence of liver cancer to varying degrees.Achieving a balance between promotion of postoperative liver regeneration and inhibition of tumor recurrence has become a major problem in liver surgery.%肝部分切除术仍是治疗肝癌的首选治疗方法,近年来大量体内及体外试验研究了促进术后肝脏再生以预防小肝综合征和肝功能衰竭发生的方法.但多项研究结果表明,肝切除术后肝再生过程可以促进肿瘤细胞的生长从而激活隐匿性微小病灶导致肿瘤复发,肝再生的三个阶段中起关键作用的细胞因子及基因均不同程度地参与了肝癌的形成、迁移、浸润和复发.如何权衡促进术后肝脏再生和抑制肿瘤复发成为肝脏外科一个亟待解决的问题,二者之间的关系十分复杂.