非细菌性血栓性心内膜炎与卒中

摘要

非细菌性血栓性心内膜炎(nonbacterial thromboendocarditis,NBTE)是一种异质性疾病,以心脏瓣膜赘生物形成为特征.NBTE与恶性肿瘤及其他原因所致的高凝状态有关,是引起隐匿性卒中的原因之一.经食道超声心动图和头颅MRI是诊断NBTE相关卒中的重要方法.合并恶性肿瘤的NBTE患者发生卒中的风险较正常人群高,短期内卒中的复发率高、预后差.因此,早期识别NBTE相关性卒中,并开展相应的治疗和二级预防是值得临床关注的问题.目前对NBTE的治疗包括原发肿瘤的治疗和抗凝治疗两部分.%Nonbacterial thromboendocarditis (NBTE) is a heterogeneous disease characterized by the formation of valve vegetations. NBTE is associated with malignancy and hypercoagulability caused by various causes, and is one of the causes of cryptogenic stroke. Transesophageal echocardiography and MRI are important examination methods to diagnose NBTE-related stroke. NBTE patients with malignant tumor have a higher risk of stroke than general population, and the recurrence rate of stroke in the short term is high and the prognosis is poor. Therefore, early identification of NBTE-related stroke, timely secondary prevention and treatment are necessary and important. Treatment of NBTE includes tumor therapy and anticoagulation therapy.