目的研究脑白质疏松（leukoaraiosis，LA）伴发认知障碍患者与健康人静息态脑网络的差异。方法分别对根据影像学及临床确诊的40例脑白质疏松伴认知障碍患者及30例年龄、性别、受教育程度均匹配的健康对照者进行静息态功能磁共振扫描，采用独立成分分析法得到两组被试者的激活区，对两组数据进行比较，得到两组间的激活差异区。结果脑白质疏松伴认知障碍患者默认网络中双侧楔前叶、左侧颞下回、左侧枕颞内侧回、右侧前扣带回激活较正常对照组减弱，左侧中央旁小叶及右侧楔叶激活程度较正常对照组增强。结论脑白质疏松伴认知障碍患者与健康人在脑静息网络激活程度上存在差异。%Objective To investigate the differences in the resting state network between patients with cognitive impairment related leukoaraiosis and normal control. Methods A total of 40 patients with leukoaraiosis related cognitive impairment diagnosed by iconographic and clinical diagnosis and 30 normal controls were included in this study. The resting-state functional magnetic resonance imaging was scanned. All subjects of the two groups were matched in age, gender and level of education. The independent component analysis was used to deal with the data, and the two-samplet-test was used to compare the differences between the two groups. Results Compared with the normal control group, leukoaraiosis patients with cognitive impairment showed significantly decreased activation at bilateral precuneus, left inferior temporal gyrus, left fusiform gyrus and right anterior cingulate; increased activation at left paracentral lobule and right cuneus; signiifcantly increased activation at left superior temporal gyrus; and signiifcantly decreased activation at bilateral cuneus, middle occipital gyrus and left lingual gyrus. Conclusion There were many differences in resting-state functional brain network between patients with cognitive impairment related leukoaraiosis and normal control.
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