Objective To explore the effect of theta burst stimulation (TBS) paradigm of repetitive transcranial magnetic stimulation (rT-MS) on executive function in patients with chronic schizophrenia. Methods 60 patients meeting DSM-IV for chronic schizophrenia disor-ders criteria were enrolled. They were randomly divided into TBS group (n=30) and sham intervention group (n=30). They were assessed with digit span performance, space span performance and Wisconsin Card Sorting Test (WCST) before and 4 weeks after intervention. Re-sults After intervention, the forward score of digit span performance, the total score and forward score of space span performance increased (P<0.05), the error selection percentage, the error selection number and the percentage of error number of WCST decreased, the percentage of conceptual level of WCST increased (P<0.05) in the TBS group. However, there was no significant difference in the digit span perfor-mance, space span performance and WSCT in the sham intervention group (P>0.05). There was significant difference in all the items be-tween 2 groups after intervention (P<0.05). Conclusion TBS paradigm of rTMS could improve the executive function in schizophrenic pa-tients.%目的 研究θ短阵快速脉冲刺激(TBS)模式的重复经颅磁刺激(rTMS)对慢性精神分裂症患者执行功能的影响.方法收集符合美国《精神障碍诊断与统计手册》第四版(DSM-Ⅳ)诊断标准的慢性精神分裂症患者60例,随机分为TBS组(n=30)和伪刺激组(n=30),予以4周的rTMS干预或伪刺激.干预前后对所有受试者予以数字广度测验、空间广度测验及威斯康星卡片分类测验(WCST)评估.结果 与干预前相比,TBS组干预后的数字广度、空间广度测验的数字广度正序分及空间广度总分、正序分均升高(均P<0.05),WSCT的选择错误率、持续性错误数及持续性错误的百分数降低,概念化水平百分数升高(均P<0.05);而伪刺激组数字广度、空间广度及WSCT各项目评分的干预前后比较均无变化(均P>0.05);干预后两组间各项目评分均有显著性差异(均P<0.05).结论 TBS模式的rTMS能够改善慢性精神分裂症患者的执行功能,并促进康复.
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