DIFFERENTIALLY EXPRESSED GENES IN HIPPOCAMPUS OF RAT BRAIN AFFECTED BY REPETITIVE TRANSCRANIAL MAGNETIC STIMULATION (RTMS) THAT USED TO THE THERAPY FOR MAJOR DEPRESSION

摘要

The present invention, repetitive transcranial magnetic stimulation (repetitive transcranial magnetic stimulation; rTMS), which is used as a method for treating depression to investigate the therapeutic effect of the molecular level, there is provided a gene group searched using a cDNA microarray (microarray) . In addition, it provides the rTMS effects on the animals to normal genes, it applied to a normal rat models for depression produced "chronic mild stress method (chronic mild stress; CMS) 'to provide Effect of genetic group.; Method of the present invention, the artificial induction of depression to rats for 4 weeks, and the treatment of chronic rTMS to the depression induced rat confirmed. For two weeks from the hippocampus (hippocampus) of rTMS Rats scoring is complete, the expression pattern of the gene were searched using the cDNA microarray. Expression of genes was analyzed in three groups (normal rat model of depression 對, false (sham) rTMS- normal rats 對 rTMS- normal rats, false (sham) rTMS- depression model 對 rTMS- depression models).; Classifying the genes that are differentially expressed between normal rats and the models of depression, and was classified rTMS-related genes that affect rTMS-related genes, affecting the normal rat model of depression. The analysis is applicable to the effects of rTMS treatment of depression as a biological indicator (biomarker) for the application and further diagnosis and treatment of depression in identifying the molecular level.