单唾液酸四己糖神经节苷酯钠注射液对痉挛型脑性瘫痪的疗效

摘要

Objective To observe the clinical effect of monosialotetrahexosyl ganglioside sodium injection (GM1) on spastic cerebral palsy. Methods 98 children with spastic cerebral palsy were randomly divided into control group (n=50) and treatment group (n=48). Both groups received Bobath approach, and the treatment group received GM1 in addition. They were assessed with Functional Independence Measure for Children (WeeFIM), Gross Motor Function Measure (GMFM) and Gesell Development Schedule (GDS) before and after 90 days of treatment. Results The scores of WeeFIM, all the dimensions of GMFM and the gross motor, fine motor, personal-social and adap-tion of the GDS improved in both groups after treatment (P<0.05), and improved more in the treatment group than in the control group (P<0.05). Conclusion GM1 may further improve the recovery of function for children with spastic cerebral palsy.%目的：观察单唾液酸四己糖神经节苷酯钠注射液(GM1)治疗痉挛型脑瘫的临床疗效。方法98例脑瘫患儿随机分为对照组(Bobath疗法)50例和治疗组(GM1加Bobath疗法)48例，治疗90 d。治疗前后采用儿童功能独立性测量(WeeFIM)、粗大运动功能测量(GMFM)和格赛尔发育量表(GDS)进行评定。结果治疗后，两组WeeFIM、GMFM和GDS中的大运动、精细动作、个人-社交和适应性均有改善(P<0.05)，治疗组较对照组改善更多(P<0.05)。结论 GM1能进一步促进痉挛型脑瘫患儿功能恢复。