目的:观察有氧运动对自发性高血压大鼠(SHR)心肌血红素氧合酶(HO)活性及HO-1 mRNA表达的影响，探讨适宜的有氧运动对高血压性心肌肥大的防治作用及机制。方法:雄性Wistar大鼠6只为正常对照组(C组)，雄性自发性高血压大鼠16只，随机分为高血压组(S组)和高血压运动组(T组)。T组每日进行60min无负重游泳，每周6次，共9周，用RT-PCR方法检测大鼠心脏HO-1 mRNA表达。结果:与C组相比，S组心肌HO活性显著降低(P＜0.05);与S组相比，T组心肌HO活性显著升高(P＜0.05)。与C组相比，各组心肌HO-1 mRNA表达差异均有显著性意义，S组心肌HO-1 mRNA表达显著升高(P＜0.01);与S组相比,T组心肌HO-1 mRNA表达也显著升高(P＜0.01)。结论:说明长期有规律的运动可以升高SHR心肌HO活性和HO-1 mRNA表达。%Objective: To investigate the effects of aerobic exercise on activity of heme oxyenase(HO) and expression of HO-1 mRNA in cardiac muscle of spontaneous hypertensive rats(SHR).Method: Male Wistar rats were assigned as follows: normal control group (C) with: 6normal rats, SHR group (S) with 8 SHRs, training SHR group (T) with 8 SHRs. T group carried on 60min unloaded swimming 6 times a week for 9 weeks. The rats in all groups were fed with normal feedstuff. Nine weeks later activity of HO and expression of HO-1 mRNA were determined by RT-PCR.Result: Activity of HO reduced significantly compared with normal control group (P < 0.05); the expression of HO-1 mRNA in S group increasd significantly compared with normal control group (P<0.01); Compared with S group, activity of HO and expression of HO-1 mRNA in T group increased obviously(P< 0.05, P<0.01). Conclusion: The long term regular aerobic exercise can increase activity of HO and expression of HO-1 mRNA obviously and improve the development of cardiac hypertrophy induced by hypertension.
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