放疗联合免疫治疗的相关机制及研究进展

摘要

近年来,恶性肿瘤的发病率越来越高,而肿瘤的各种治疗技术也在不断提高,治疗方案不断完善.放疗主要是通过放射线对局部肿瘤细胞的杀伤来达到治疗效果,而在放疗过程中,可以诱导或提高抗肿瘤免疫反应.合适的放疗剂量、分割模式联合一定的免疫治疗在肿瘤的治疗中越来越起到重要的作用.本文综述了放疗增强抗肿瘤免疫反应的相关机制及放疗联合免疫治疗研究现状和发展前景.%In recent years, the incidence rate of malignant tumors has been ever increased. As the persistent advancement of various therapeutic techniques, the therapeutic plans of cancer have been improved. Radiotherapy takes effect mainly by killing the topical tumor cells by radiation. During radiotherapy, the anti-tumor immune response can be induced or enhanced. Appropriate radiotherapy dose and segmentation model combined with certain immunotherapy plays a more and more significant role in the treatment of tumors. In this article, the underlying mechanisms of radiation-enhanced anti-tumor immune response and the current status and research prospects of radiotherapy combined with immunotherapy were reviewed.