食管癌根治性调强放疗大体肿瘤体积因素与靶区内放疗失败的关系

摘要

Objective Investigate the relationship between gross tumor volume (GTV)-related factors including GTV-T volume,the maximum thickness of the esophageal lesion plane and GTV-T volume/length(GTV-T volume divided by the length of the lesion calculated by the number of GTV-T layers) and the locoregional failure of radical intensity-modulated radiation therapy (IMRT) for esophageal carcinoma.Methods A total of 133 patients with esophageal cancer undergoing radical IMRT were enrolled.The factors related to GTV-T including GTV-T volume,the maximum thickness of the esophageal lesions,GTV-T volume/length were calculated.The relationship between GTV-T related factors and local recurrence of tumors was retrospectively analyzed.Results There was positively linear association between the locoregional failure rate of GTV-T and the volume of GTV-T.The volume of GTV-T tumor was 36 cm3,the maximum wall thickness was 2.5 cm,and the GTV-T volume/length was calculated as 5.3 cm2.These critical values could be utilized to predict the risk of locoregional failure of IMRT for esophageal carcinoma.Conclusions The GTV-T factors can be adopted to predict the local control and the risk of locoregional failure of radical IMRT for esophageal carcinoma to certain extent.%目的 回顾性分析GTV-T因素与肿瘤局部失败的关系.方法 整理并计算133例行根治性调强放疗的食管癌患者GTV-T因素.包括:GTV-T体积,GTV-T最大管壁厚度(GTV-T区域中食管平面最大厚度),GTV-T体积/长度(GTV-T体积除以GTV-T层面数计算病变长度).结果 GTV-T区域治疗失败率与GTV-T体积呈正相关线性趋势关系.GTV-T肿瘤体积为36 cm3,最大管壁厚度为2.5cm,以及体积/长度为5.3 cm2,可作为预估食管癌放疗失败风险的临界值.结论 根治性调强放疗大体肿瘤体积(GTV-T)因素能在一定程度上预示食管癌根治性放疗后局部控制情况,预估食管癌的放疗失败风险.