聚腺苷二磷酸核糖聚合酶抑制剂联合放疗研究进展

摘要

As a DNA damage sensor,poly (ADP-ribose) polymerase (PARP) is involved in a wide variety of cellular activities,such as DNA damage repair.PARP inhibitors regulate a series of cellular activities by inhibiting PARP function,which have become a focus of current research.Recently,several in vivo and in vitro studies showed that PARP inhibitors combined with radiotherapy effectively enhanced the efficacy of radiotherapy.This paper reviews the research advances in the mechanisms of action of PARP inhibitors and their combination with radiotherapy.%聚腺苷二磷酸核糖聚合酶(PARP)作为DNA损伤的感受器广泛参与体内如DNA损伤修复等多种细胞活动,PARP抑制剂则可以通过抑制PARP的功能从而影响细胞一系列的细胞活动而成为当前研究的热点.目前多个体内外实验结果显示PARP抑制剂联合放疗可有效增强放疗疗效,本文就PARP抑制剂的原理及其联合放疗的研究进展进行综述.