多聚腺苷二磷酸核糖聚合酶及其抑制剂与炎症治疗的研究进展

摘要

多聚腺苷二磷酸核糖聚合酶(PA RP)是近年发现的治疗炎性疾病的一个新靶点,其过度活化能在基因水平调节炎症相关因子,如核因子-κB、诱导型一氧化氮合酶、激活蛋白-1、热休克蛋白1等的表达,从而导致细胞变性坏死,引起炎症反应.因此PARP被认为是炎性疾病发病的诱因之一,抑制PARP的活性将为治疗炎性疾病带来新的希望.本文就PARP的蛋白结构和功能及其在炎症中的作用机制,以及PARP抑制剂在炎性疾病治疗中的应用研究作一综述.%Poly ADP-ribose polymerase (PARP) is a new-found target in the treatment of inflammatory. Its excessive activation will affect the expression of the inflammation-related factors such as nuclear factor-κB, inducible nitric oxide, activator protein-1 and heat shock factor protein 1, which lead to cell degeneration and necrosis, ultimately causing inflammation. Therefore, inhibition of PARP will bring a new hope for the treatment of inflammatory diseases. In this article, the protein structure and function of PARP, the mechanism of its action in inflammation, and the application of PARP inhibitors in the treatment of inflammatory diseases are reviewed.