全氟有机化合物:具有潜在健康风险的新型环境污染物

摘要

Perfluoroalkyl substances (PFASs) have been distributed in environment and human body worldwide.Due to their bioaccumulative and multiple organ toxic,these compounds have raised more and more attention in recent years.The precursors of PFASs can be metabolized to PFASs both in environment and human body,which makes an important contribution to human body burdens.Apart from transformation into PFASs,some of these precursors themselves or their metabolic intermediates also have toxicity effects,such as estrogen-like properties,protein binding,cytotoxicity and so on,and there might be a potential harmful impact on human health.In this paper,the toxicity and biotransformation of PFASs and their precursors were introduced briefly.%全氟有机化合物在环境和人体中广泛分布,这类物质具有生物富集性、多器官毒性,近年来在环境健康研究领域受到了越来越多的关注.这类物质的重要暴露来源是其前体物质在环境中和生物体内转化.此外,这些前体物质自身或代谢中间体也发现了一定的生物学毒性,如类激素作用、蛋白偶联和细胞毒性等等.本文对于近年来全氟有机化合物及其前体物质的毒性和转化等方面的研究进展进行了简要介绍.