有机氯类杀虫剂对脂质代谢异常的影响

摘要

Dyslipidemias is one important risk factor associated with chronic diseases.Persistent organic pollutants are resistant to degradation and can be bio-accumulated and magnified through the food chain.Recently,the relation between dyslipidemias and organochlorine pesticides has attracted more attentions.In this review,we explored the distribution of organochloride pesticides in the environment and human body,as well as the possible underlying mechanisms of the association between dyslipidemias and organochloride pesticides,including accumulation and release of organochloride,simulation of estrogen,impact on PPARs,the metabolic fingerprint,and the inflammatory reaction.%脂质代谢异常是诸多慢性疾病的主要危险因素之一.有机氯类杀虫剂作为持久性有机污染物的一种,难以降解且易于生物富集,并可通过食物链引起生物放大作用.近年来,有机氯类杀虫剂与脂质代谢异常的关系逐渐引起关注.本文综述了有机氯杀虫剂化学成分的环境分布及人群内暴露数据的研究进展,并从其蓄积与释放、模拟雌激素作用、对过氧化物酶体增殖物激活受体的影响、代谢谱以及炎性反应等方面探讨有机氯杀虫剂所致脂质代谢异常的可能机制.