有机氯杀虫剂致脂肪酸和胆汁酸代谢异常的研究进展

摘要

Organochlorine pesticides(OCP)exist widely in the environment,which may threaten human health and cumulate for years once absorbed in the body.OCP metabolites in the body are associated with metabolic disorders.In vivo and in vitro exposure of OCP could enhance hepatic fatty acid synthesis, and interfere in the β-oxidation of fatty acids by impairing the function and structure of mitochondria in hepatocytes. Moreover, OCP can increase secondary bile acid formation by modulating of gut microbiota and reduceing ileal bile acid re-absorption,resulting in compensatory increase of hepatic bile acid synthesis. This review summarizes the mechanism of fatty acid and bile acid metabolic abnormalities caused by OCP.%有机氯杀虫剂(OCP)广泛存在于环境中,被人体吸收后可在体内累积数年并危及健康.OCP与多种代谢异常所致的疾病有关.体内、外研究发现,OCP暴露可增加脂肪酸合成,并因损伤肝线粒体结构功能而影响脂肪酸β-氧化.另外,OCP可通过影响小鼠肠道菌群促进次级胆汁酸形成,降低肠道对胆汁酸重吸收,进而促进肝代偿性胆汁酸合成.本文对OCP导致脂肪酸和胆汁酸代谢异常的机制进行了综述.